The auction house will accept bitcoin or ether for Banksy's “Laugh Now Panel A,” valued at between $2.82 million and $4.1 million.
Cryptocurrency exchange Coinbase is partnering with the auction house for the groundbreaking sale.
Winners will receive both the DNS TLD and an NFT representing the ENS version.
The GSA's next BTC auction could fetch more than $300K, generating even more excitement among cryptocurrency investors.
The General Services Administration has been auctioning bitcoin since 2014, when the FBI shut down the Silk Road black market.
The U.S. Marshals are set to auction off about 660 bitcoin forfeited in federal criminal, civil and administrative cases, worth about $4.3 million.
The U.S. Marshals auctioned more than 2,100 bitcoins off on March 19.
The U.S. Marshals will auction off 2,170 bitcoins worth roughly $25 million in two weeks.
The U.S. agency that manages the sale of seized assets confirmed Thursday it had successfully auctioned off more than 3,600 bitcoin in January.
The U.S. Marshals Service has announced that it will auction off more than 3,800 bitcoins later this month.
The convicted operator of the Silk Road dark market has given up his claim to over $48 million raised after the sale of more than 144,000 bitcoins.
The South Korea government plans to auction 216 bitcoins that it confiscated during a 2016 criminal investigation.
A winning bidder has claimed 2,700 BTC (worth $1.58m) at an auction held by the US Marshals Service (USMS).